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ABCD3
Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family |
| Chromosomal Location of mouse Ortholog: 3 G1|3 52.94 cM |
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Cellular Component:
intracellular membrane-bounded organelle; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome
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Molecular Function:
ABC-type transporter activity; acyl-CoA hydrolase activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; hydrolase activity; long-chain fatty acid transporter activity; nucleotide binding; protein binding; protein homodimerization activity; protein self-association
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Biological Process:
bile acid and bile salt transport; bile acid biosynthetic process; fatty acid beta-oxidation; fatty acid biosynthetic process; lipid transport; long-chain fatty acid import into peroxisome; peroxisome organization; phytanic acid metabolic process; transmembrane transport; very long-chain fatty acid catabolic process; very long-chain fatty acid metabolic process
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Reference #:
P55096
(UniProtKB)
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Alt. Names/Synonyms: 68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; Abcd3; AI313901; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; AU018866; AW146054; peroxisomal membrane protein 1; peroxisomal membrane protein, 70 kDa; PMP; PMP68; PMP70; Pxm; Pxmp1
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Gene Symbols: Abcd3
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Molecular weight:
75,475 Da
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Basal Isoelectric point:
9.32
Predict pI for various phosphorylation states
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