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P2Y2
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP Belongs to the G-protein coupled receptor 1 family. Spleen, testis, kidney, liver, lung, heart and brain. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. |
| Chromosomal Location of human Ortholog: 11q13.4 |
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Cellular Component:
integral component of plasma membrane; plasma membrane
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Molecular Function:
G protein-coupled purinergic nucleotide receptor activity; signaling receptor activity
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Biological Process:
cellular ion homeostasis; cellular response to ATP; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of mucus secretion; regulation of blood vessel diameter
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Reference #:
P41231
(UniProtKB)
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Alt. Names/Synonyms: ATP receptor; HP2U; MGC20088; MGC40010; P2RU1; P2RY2; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 2; purinergic receptor P2Y2; purinoceptor P2Y2
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Gene Symbols: P2RY2
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Molecular weight:
42,273 Da
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Basal Isoelectric point:
9.72
Predict pI for various phosphorylation states
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