P2Y2 Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP Belongs to the G-protein coupled receptor 1 family. Spleen, testis, kidney, liver, lung, heart and brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc.
Chromosomal Location of human Ortholog: 11q13.4
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  G protein-coupled purinergic nucleotide receptor activity; signaling receptor activity
Biological Process:  cellular ion homeostasis; cellular response to ATP; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of mucus secretion; regulation of blood vessel diameter
Reference #:  P41231 (UniProtKB)
Alt. Names/Synonyms: ATP receptor; HP2U; MGC20088; MGC40010; P2RU1; P2RY2; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 2; purinergic receptor P2Y2; purinoceptor P2Y2
Gene Symbols: P2RY2
Molecular weight: 42,273 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein