DENND1B Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells. Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 1q31.3
Cellular Component:  clathrin-coated vesicle; cytosol; nuclear speck
Molecular Function:  Rab guanyl-nucleotide exchange factor activity
Biological Process:  endocytic recycling; positive regulation of GTPase activity; protein transport; regulation of immune response; T cell receptor signaling pathway; T-helper 2 cell cytokine production
Reference #:  Q6P3S1 (UniProtKB)
Alt. Names/Synonyms: C1ORF18; C1orf218; Connecdenn 2; DEN1B; DENN domain containing 1B; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; DENND1B; DKFZp547O0715; FAM31B; family with sequence similarity 31, member B; FLJ20054; FLJ21179; FLJ33888; MGC103810; MGC27044; Protein FAM31B
Gene Symbols: DENND1B
Molecular weight: 86,552 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein