CYP1A2 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity).
Protein type: Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of rat Ortholog: 8q24
Cellular Component:  endoplasmic reticulum membrane; intracellular membrane-bounded organelle
Molecular Function:  aromatase activity; caffeine oxidase activity; demethylase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Biological Process:  alkaloid metabolic process; cellular aromatic compound metabolic process; cellular respiration; cellular response to cadmium ion; cellular response to copper ion; dibenzo-p-dioxin metabolic process; drug catabolic process; drug metabolic process; exogenous drug catabolic process; heterocycle metabolic process; hydrogen peroxide biosynthetic process; lung development; monocarboxylic acid metabolic process; monoterpenoid metabolic process; oxidation-reduction process; oxidative deethylation; oxidative demethylation; porphyrin-containing compound metabolic process; post-embryonic development; regulation of gene expression; response to drug; response to estradiol; response to immobilization stress; response to lipopolysaccharide; response to organic cyclic compound; response to organic substance; steroid catabolic process; toxin biosynthetic process; toxin metabolic process; xenobiotic metabolic process
Reference #:  P04799 (UniProtKB)
Alt. Names/Synonyms: CYP1A2; CYPIA2; Cytochrome P-448; Cytochrome P-450d; Cytochrome P450 1A2; Cytochrome P450-D
Gene Symbols: Cyp1a2
Molecular weight: 58,259 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CYP1A2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene