ARF GAP 3 GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  cytosol; Golgi apparatus; Golgi membrane
Molecular Function:  GTPase activator activity; metal ion binding; protein binding
Biological Process:  ER to Golgi vesicle-mediated transport; intracellular protein transport; positive regulation of GTPase activity; protein secretion; retrograde vesicle-mediated transport, Golgi to ER; vesicle-mediated transport
Reference #:  Q9NP61 (UniProtKB)
Alt. Names/Synonyms: ADP ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ARFG3; ARFGAP1; ARFGAP3; FLJ45618
Gene Symbols: ARFGAP3
Molecular weight: 56,928 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein