RAB18 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. Belongs to the small GTPase superfamily. Rab family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 10p12.1
Cellular Component:  cytosol; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; plasma membrane; secretory granule membrane; synapse
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding
Biological Process:  brain development; endoplasmic reticulum tubular network organization; eye development; lipid droplet organization; neutrophil degranulation; small GTPase mediated signal transduction
Disease: Warburg Micro Syndrome 3
Reference #:  Q9NP72 (UniProtKB)
Alt. Names/Synonyms: RAB18; RAB18 small GTPase; RAB18, member RAS oncogene family; RAB18LI1; Ras-related protein Rab-18; WARBM3
Gene Symbols: RAB18
Molecular weight: 22,977 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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RAB18

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene