MYO7A Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component:  apical plasma membrane; cell cortex; cytoplasm; cytosol; lysosomal membrane; melanosome; microvillus; myosin VII complex; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment; stereocilium; stereocilium base; synapse; upper tip-link density
Molecular Function:  actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; calmodulin binding; microfilament motor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein N-terminus binding; spectrin binding
Biological Process:  actin filament-based movement; auditory receptor cell stereocilium organization; cellular protein localization; equilibrioception; eye photoreceptor cell development; intracellular protein transport; lysosome organization; mechanoreceptor differentiation; phagolysosome assembly; pigment granule transport; post-embryonic animal organ morphogenesis; sensory perception of light stimulus; sensory perception of sound; visual perception
Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I
Reference #:  Q13402 (UniProtKB)
Alt. Names/Synonyms: deafness, autosomal dominant 11; deafness, autosomal recessive 2; DFNA11; DFNB2; MYO7A; myosin VIIA; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); Myosin-VIIa; MYOVIIA; MYU7A; NSRD2; Unconventional myosin-VIIa; USH1B
Gene Symbols: MYO7A
Molecular weight: 254,390 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein