SLAP-130 Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component:  actin cytoskeleton; cell junction; cytosol; nucleus
Molecular Function:  lipid binding; protein binding; protein-containing complex binding; signaling receptor binding
Biological Process:  immune response; T cell receptor signaling pathway
Disease: Thrombocytopenia 3
Reference #:  O15117 (UniProtKB)
Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130; FYN binding protein (FYB-120/130); FYN-binding protein; FYN-binding protein (FYB-120/130); FYN-binding protein 1; FYN-T-binding protein; p120/p130; PRO0823; SLAP-130; SLAP130; SLP-76-associated phosphoprotein
Gene Symbols: FYB1
Molecular weight: 85,387 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLAP-130

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB