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SLAP-130
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 5p13.1 |
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Cellular Component:
actin cytoskeleton; anchoring junction; cytosol; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
lipid binding; protein binding; protein-containing complex binding; signaling receptor binding
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Biological Process:
immune response; integrin-mediated signaling pathway; protein localization to plasma membrane; T cell receptor signaling pathway
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Disease: Thrombocytopenia 3
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Reference #:
O15117
(UniProtKB)
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Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130; FYB1; FYN binding protein (FYB-120/130); FYN binding protein 1; FYN-binding protein; FYN-binding protein (FYB-120/130); FYN-binding protein 1; FYN-T-binding protein; p120/p130; PRO0823; SLAP-130; SLAP130; SLP-76-associated phosphoprotein; THC3
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Gene Symbols: FYB1
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Molecular weight:
85,387 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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