EPCR Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component:  centrosome; extracellular region; integral component of plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  blood coagulation; negative regulation of coagulation
Reference #:  Q9UNN8 (UniProtKB)
Alt. Names/Synonyms: Activated protein C receptor; APC receptor; bA42O4.2; CCCA; CCD41; CD201; CD201 antigen; cell cycle, centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; MGC23024; PROCR; protein C receptor, endothelial (EPCR)
Gene Symbols: PROCR
Molecular weight: 26,671 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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EPCR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene