REV3 Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Belongs to the DNA polymerase type-B family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Transferase
Chromosomal Location of human Ortholog: 6q21
Cellular Component:  nucleolus; nucleoplasm; zeta DNA polymerase complex
Molecular Function:  4 iron, 4 sulfur cluster binding; DNA binding; DNA-directed DNA polymerase activity; metal ion binding; nucleotide binding; protein binding
Biological Process:  DNA-dependent DNA replication; error-prone translesion synthesis; nucleic acid phosphodiester bond hydrolysis
Reference #:  O60673 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase zeta catalytic subunit; DPOLZ; hREV3; Polymerase, DNA, zeta (Rev-3, yeast, homolog of); POLZ; Protein reversionless 3-like; Rev-3, yeast, homolog-like (polymerase, DNA, zeta); REV3; REV3 like, DNA directed polymerase zeta catalytic subunit; REV3-like; REV3-like, catalytic subunit of DNA polymerase zeta (yeast); REV3-like, polymerase (DNA directed), zeta, catalytic subunit; REV3L
Gene Symbols: REV3L
Molecular weight: 352,776 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene