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HRC1
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 11p15.5 |
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Cellular Component:
centriolar satellite; cytoplasm
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Molecular Function:
protein binding
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Biological Process:
apoptotic process; signal transduction
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Reference #:
Q02833
(UniProtKB)
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Alt. Names/Synonyms: C11orf13; CFAP88; FAP88; HRAS1; HRAS1-related cluster protein 1; HRAS1-related cluster-1; HRC1; MGC126069; MGC126070; Ras association (RalGDS/AF-6) domain family (N-terminal) member 7; Ras association (RalGDS/AF-6) domain family 7; Ras association domain family member 7; Ras association domain-containing protein 7; RASF7; RASSF7
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Gene Symbols: RASSF7
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Molecular weight:
39,945 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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