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ADD2
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Belongs to the aldolase class II family. Adducin subfamily. Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2p13.3 |
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Cellular Component:
cytoplasmic vesicle; cytoskeleton; cytosol; F-actin capping protein complex; plasma membrane; plasma membrane raft; postsynaptic density
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Molecular Function:
actin binding; actin filament binding; calmodulin binding; molecular adaptor activity; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; spectrin binding; structural constituent of cytoskeleton
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Biological Process:
actin cytoskeleton organization; actin filament bundle assembly; barbed-end actin filament capping; hemopoiesis; leukocyte migration; leukocyte tethering or rolling; positive regulation of protein binding; protein-containing complex assembly; synapse assembly
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Reference #:
P35612
(UniProtKB)
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Alt. Names/Synonyms: ADD2; ADDB; adducin 2; adducin 2 (beta); Adducin-2 (beta); beta adducin; Beta-adducin; Erythrocyte adducin subunit beta
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Gene Symbols: ADD2
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Molecular weight:
80,854 Da
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Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
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