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JIP4
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Belongs to the JIP scaffold family. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA) |
| Chromosomal Location of mouse Ortholog: 11|11 D |
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Cellular Component:
centriolar satellite; cytoplasm; cytosol; lysosomal membrane; lysosome; membrane
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Molecular Function:
identical protein binding; JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; protein binding; signaling receptor complex adaptor activity
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Biological Process:
lysosome localization; negative regulation of dendrite extension; negative regulation of neuron differentiation; negative regulation of protein phosphorylation; positive regulation of cell migration; positive regulation of MAPK cascade; positive regulation of neuron differentiation; retrograde transport, endosome to Golgi; striated muscle cell differentiation; vesicle-mediated transport
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Reference #:
Q58A65
(UniProtKB)
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Alt. Names/Synonyms: 3110018C07Rik; 4733401I23Rik; 4831406C20Rik; AW552012; C-Jun-amino-terminal kinase-interacting protein 4; CT89; JIP-4; Jip4; JLP; JNK-associated leucine-zipper protein; JNK-interacting leucine zipper; JNK-interacting protein 4; JNK/SAPK-associated protein 2; JSAP2; JSAP2a; Kiaa0516; Mapk; Mapk8ip4; Mitogen-activated protein kinase 8-interacting protein 4; OTTMUSP00000001565; OTTMUSP00000001568; Spag9; sperm associated antigen 9; Sperm-associated antigen 9; syd; syd1
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Gene Symbols: Spag9
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Molecular weight:
146,219 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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