MLL2 Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Transcription factor
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  histone methyltransferase complex; nucleus
Molecular Function:  DNA binding; histone methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity; zinc ion binding
Biological Process:  chromatin organization; gene silencing; histone H3-K4 methylation; histone H3-K4 trimethylation; histone lysine methylation; memory; methylation; oocyte differentiation; ovarian follicle development; ovulation; positive regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation; regulation of transcription, DNA-templated
Reference #:  O08550 (UniProtKB)
Alt. Names/Synonyms: 2610014H22Rik; Histone-lysine N-methyltransferase 2B; Histone-lysine N-methyltransferase MLL4; Kmt2b; mixed lineage leukemia 2; mKIAA0304; Mll2; MLL4; Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog; OTTMUSP00000028341; Trithorax homolog 2; Trx2; WBP-7; Wbp7; WW domain binding protein 7; WW domain-binding protein 7
Gene Symbols: Kmt2b
Molecular weight: 294,821 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MLL2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene