PCM-1 Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. Belongs to the PCM1 family. Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 8 A4|8 23.89 cM
Cellular Component:  apical part of cell; cell projection; centriolar satellite; centriole; centrosome; ciliary basal body; ciliary transition zone; cytoplasm; cytoskeleton; cytosol; nuclear membrane; pericentriolar material; protein-containing complex
Molecular Function:  protein binding
Biological Process:  cell projection organization; centrosome cycle; cilium assembly; cytoplasmic microtubule organization; interkinetic nuclear migration; intraciliary transport involved in cilium assembly; microtubule anchoring; microtubule anchoring at centrosome; negative regulation of neurogenesis; neuron migration; neuronal stem cell population maintenance; non-motile cilium assembly; positive regulation of intracellular protein transport; protein localization to centrosome; protein localization to organelle; social behavior
Reference #:  Q9R0L6 (UniProtKB)
Alt. Names/Synonyms: 2600002H09Rik; 9430077F19Rik; C030044G17Rik; MGC170660; mPCM-1; PCM-1; Pcm1; pericentriolar material 1; Pericentriolar material 1 protein; pericentriolar material gene 1
Gene Symbols: Pcm1
Molecular weight: 228,847 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PCM-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene