USP10 Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Belongs to the peptidase C19 family. USP10 subfamily. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  cytoplasm; cytosol; early endosome; endosome; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; ion channel binding; p53 binding; peptidase activity; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  autophagy; cellular response to DNA damage stimulus; cellular response to interleukin-1; DNA damage response, signal transduction by p53 class mediator; DNA repair; negative regulation of I-kappaB kinase/NF-kappaB signaling; protein deubiquitination; regulation of autophagy; ubiquitin-dependent protein catabolic process
Reference #:  P52479 (UniProtKB)
Alt. Names/Synonyms: 2610014N07Rik; Deubiquitinating enzyme 10; Kiaa0190; mKIAA0190; Ode-1; OTTMUSP00000032197; ubiquintin c-terminal hydrolase related polypeptide; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10; UBP10; UBPO; Uch; Uchrp; Usp10
Gene Symbols: Usp10
Molecular weight: 87,022 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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USP10

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene