TSC1
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1. Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis; Tumor suppressor |
Chromosomal Location of rat Ortholog: 3p12 |
Cellular Component:
actin filament; cell cortex; cell projection; cytoplasm; cytosol; growth cone; lamellipodium; lipid droplet; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein folding chaperone complex; protein-containing complex; TSC1-TSC2 complex
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Molecular Function:
ATPase inhibitor activity; Hsp70 protein binding; Hsp90 protein binding; protein binding; protein-folding chaperone binding
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Biological Process:
activation of GTPase activity; adaptive immune response; adult locomotory behavior; associative learning; cardiac muscle cell differentiation; cell population proliferation; cell projection organization; cell-matrix adhesion; cellular response to oxygen-glucose deprivation; cerebral cortex development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of ATP-dependent activity; negative regulation of cell population proliferation; negative regulation of cell size; negative regulation of cellular response to oxidative stress; negative regulation of GTPase activity; negative regulation of macroautophagy; negative regulation of neuron projection development; negative regulation of TOR signaling; negative regulation of translation; nervous system development; neural tube closure; positive regulation of focal adhesion assembly; positive regulation of macroautophagy; positive regulation of stress fiber assembly; potassium ion transport; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of focal adhesion assembly; regulation of neuron death; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber assembly; regulation of translation; response to insulin; response to nutrient levels; response to peptide; rRNA export from nucleus; synapse organization
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Reference #:
Q9Z136
(UniProtKB)
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Alt. Names/Synonyms: Hamartin; Tsc1; tuberous sclerosis 1; Tuberous sclerosis 1 protein homolog
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Gene Symbols: Tsc1
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Molecular weight:
129,022 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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