MEF2D Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis. Belongs to the MEF2 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 1q22
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  activating transcription factor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  adult heart development; apoptotic process; chondrocyte differentiation; endochondral ossification; muscle organ development; nervous system development; osteoblast differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular smooth muscle cell proliferation; skeletal muscle cell differentiation
Reference #:  Q14814 (UniProtKB)
Alt. Names/Synonyms: DKFZp686I1536; MADS box transcription enhancer factor 2, polypeptide D; MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D); MEF2D; MEF2D/DAZAP1 fusion; myocyte enhancer factor 2D; myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein; Myocyte-specific enhancer factor 2D
Gene Symbols: MEF2D
Molecular weight: 55,938 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene