p47phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Detected in peripheral blood monocytes and neutrophils (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Oxidoreductase
Chromosomal Location of rat Ortholog: 12q12
Cellular Component:  cytoplasm; cytosol; dendrite; extrinsic component of membrane; Golgi apparatus; membrane; NADPH oxidase complex; neuronal cell body; plasma membrane; rough endoplasmic reticulum
Molecular Function:  phosphatidylinositol binding; phosphatidylinositol-3,4-bisphosphate binding; SH3 domain binding; superoxide-generating NADPH oxidase activator activity; superoxide-generating NADPH oxidase activity
Biological Process:  apoptotic process; cell proliferation; cellular defense response; cellular response to cadmium ion; cellular response to reactive oxygen species; defense response to bacterium; defense response to fungus; defense response to Gram-positive bacterium; hydrogen peroxide biosynthetic process; inflammatory response; leukocyte mediated cytotoxicity; leukotriene metabolic process; negative regulation of smooth muscle contraction; neutrophil mediated killing of fungus; neutrophil mediated killing of gram-positive bacterium; oxidation-reduction process; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of transcription, DNA-templated; protein targeting to membrane; respiratory burst; respiratory burst involved in defense response; response to bacterium; response to yeast; superoxide anion generation; superoxide metabolic process
Reference #:  F1M707 (UniProtKB)
Alt. Names/Synonyms: Ncf-1; Ncf1; Neutrophil cytosolic factor 1; P47 phox; p47phox; phagocyte oxidase 47 kDa
Gene Symbols: Ncf1
Molecular weight: 44,712 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein