p47phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Detected in peripheral blood monocytes and neutrophils (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Oxidoreductase
Chromosomal Location of human Ortholog: 7q11.23
Cellular Component:  cytosol; dendrite; extrinsic component of membrane; Golgi apparatus; NADPH oxidase complex; neuronal cell body; phagolysosome; plasma membrane; rough endoplasmic reticulum
Molecular Function:  electron transfer activity; phosphatidylinositol binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; SH3 domain binding; superoxide-generating NADPH oxidase activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cell redox homeostasis; cellular defense response; cellular response to cadmium ion; cellular response to oxidative stress; cellular response to reactive oxygen species; electron transport chain; innate immune response; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of transcription, DNA-templated; protein targeting to membrane; respiratory burst; superoxide anion generation; superoxide metabolic process; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I
Reference #:  P14598 (UniProtKB)
Alt. Names/Synonyms: 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; CGD1; FLJ79451; NADPH oxidase organizer 2; NCF-1; NCF-47K; NCF1; NCF1A; Neutrophil cytosol factor 1; neutrophil cytosolic factor 1; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; NOXO2; p47-phox; p47phox; SH3 and PX domain-containing protein 1A; SH3PXD1A
Gene Symbols: NCF1
Molecular weight: 44,682 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB