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p47phox
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Detected in peripheral blood monocytes and neutrophils (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.-.-.-; Oxidoreductase |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendrite; membrane; NADPH oxidase complex; neuronal cell body; phagolysosome; plasma membrane
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Molecular Function:
electron transfer activity; phosphatidylinositol binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; SH3 domain binding; superoxide-generating NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activator activity
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Biological Process:
cellular defense response; cellular response to cadmium ion; cellular response to glucose stimulus; cellular response to reactive oxygen species; cellular response to testosterone stimulus; electron transport chain; innate immune response; positive regulation of DNA-templated transcription; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; protein targeting to membrane; reactive oxygen species biosynthetic process; regulation of respiratory burst involved in inflammatory response; respiratory burst; superoxide anion generation; superoxide metabolic process
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Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I
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Reference #:
P14598
(UniProtKB)
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Alt. Names/Synonyms: 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; CGD1; FLJ79451; NADPH oxidase organizer 2; NCF-1; NCF-47K; NCF1; NCF1A; Neutrophil cytosol factor 1; neutrophil cytosolic factor 1; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; NOXO2; p47-phox; p47phox; SH3 and PX domain-containing protein 1A; SH3PXD1A
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Gene Symbols: NCF1
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Molecular weight:
44,682 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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