Lyric Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Nucleolus
Chromosomal Location of human Ortholog: 8q22.1
Cellular Component:  apical plasma membrane; bicellular tight junction; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; fibrillar center; intercellular canaliculus; nuclear body; nuclear membrane; nucleus; perinuclear region of cytoplasm
Molecular Function:  double-stranded RNA binding; NF-kappaB binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transcription coregulator activity
Biological Process:  DNA-templated transcription; lipopolysaccharide-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; regulation of transcription by RNA polymerase II
Reference #:  Q86UE4 (UniProtKB)
Alt. Names/Synonyms: 3D3; 3D3/LYRIC; AEG-1; AEG1; astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC
Gene Symbols: MTDH
Molecular weight: 63,837 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene