JIP4 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  acrosomal vesicle; cytosol; microtubule organizing center; perinuclear region of cytoplasm
Molecular Function:  protein binding
Biological Process:  positive regulation of cell migration; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; protein homooligomerization; retrograde transport, endosome to Golgi; striated muscle cell differentiation
Reference #:  O60271 (UniProtKB)
Alt. Names/Synonyms: c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; Cancer/testis antigen 89; CT89; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC-4 protein; HLC-6; HLC4; HSS; Human lung cancer oncogene 6 protein; JIP-4; JIP4; JLP; JNK interacting protein; JNK-associated leucine-zipper protein; JNK-interacting protein 4; JNK/SAPK-associated protein; KIAA0516; lung cancer oncogene 4; MAPK8IP4; Max-binding protein; MGC117291; MGC14967; MGC74461; Mitogen-activated protein kinase 8-interacting protein 4; PHET; PIG6; proliferation-inducing gene 6; Proliferation-inducing protein 6; Protein highly expressed in testis; SPAG9; sperm associated antigen 9; sperm specific protein; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1; SYD1
Gene Symbols: SPAG9
Molecular weight: 146,205 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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