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WWP1
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 8q21.3 |
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Cellular Component:
cytoplasm; cytosol; nucleus; plasma membrane; ubiquitin ligase complex
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Molecular Function:
protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
central nervous system development; monoatomic ion transmembrane transport; negative regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; signal transduction; viral entry into host cell
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Reference #:
Q9H0M0
(UniProtKB)
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Alt. Names/Synonyms: AIP5; atrophin-1 interacting protein 5; Atrophin-1-interacting protein 5; DKFZp434D2111; HECT-type E3 ubiquitin transferase WWP1; hSDRP1; Nedd-4-like ubiquitin-protein ligase; NEDD4-like E3 ubiquitin-protein ligase WWP1; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP1
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Gene Symbols: WWP1
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Molecular weight:
105,202 Da
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Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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