CAMK2A iso2 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 5q32
Cellular Component:  calcium- and calmodulin-dependent protein kinase complex; cell junction; cytosol; dendritic spine; endocytic vesicle membrane; mitochondrion; nucleoplasm; postsynaptic density; postsynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; glutamate receptor binding; identical protein binding; kinase activity; metal ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process:  angiotensin-activated signaling pathway; calcium ion transport; dendrite morphogenesis; dendritic spine development; G1/S transition of mitotic cell cycle; interferon-gamma-mediated signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine autophosphorylation; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of cellular response to heat; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of neuron migration; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; regulation of synaptic vesicle docking; response to ischemia; Wnt signaling pathway, calcium modulating pathway
Reference #:  Q9UQM7-2 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calmodulin-dependent kinase II; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMK2A iso2; CAMKA; CaMKIIalpha; CaMKIINalpha; KCC2A; KIAA0968; MRD53; MRT63
Gene Symbols: CAMK2A
Molecular weight: 55,320 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
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CAMK2A iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene