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SRm300
Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family. Expressed in liver, placenta, and white blood cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
Cajal body; catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome
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Molecular Function:
C2H2 zinc finger domain binding; mRNA binding; protein binding
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Biological Process:
mRNA splicing, via spliceosome
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Disease: Intellectual Developmental Disorder, Autosomal Dominant 72
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Reference #:
Q9UQ35
(UniProtKB)
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Alt. Names/Synonyms: 300 kDa nuclear matrix antigen; 300-KD; Cwc21; CWF21; DKFZp667L0421; DKFZp686O15166; FLJ21926; FLJ22250; HSPC075; KIAA0324; MGC40295; RNA binding protein; Ser/Arg-related nuclear matrix protein of 300 kDa; serine/arginine repetitive matrix 2; Serine/arginine repetitive matrix protein 2; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; Splicing coactivator subunit SRm300; SR-related nuclear matrix protein of 300 kDa; SRL300; SRM300; SRRM2; Tax-responsive enhancer element-binding protein 803; TaxREB803; testicular secretory protein Li 53
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Gene Symbols: SRRM2
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Molecular weight:
299,615 Da
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Basal Isoelectric point:
12.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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