SRm300 Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family. Expressed in liver, placenta, and white blood cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  Cajal body; catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome
Molecular Function:  C2H2 zinc finger domain binding; mRNA binding; protein binding
Biological Process:  mRNA splicing, via spliceosome
Disease: Intellectual Developmental Disorder, Autosomal Dominant 72
Reference #:  Q9UQ35 (UniProtKB)
Alt. Names/Synonyms: 300 kDa nuclear matrix antigen; 300-KD; Cwc21; CWF21; DKFZp667L0421; DKFZp686O15166; FLJ21926; FLJ22250; HSPC075; KIAA0324; MGC40295; RNA binding protein; Ser/Arg-related nuclear matrix protein of 300 kDa; serine/arginine repetitive matrix 2; Serine/arginine repetitive matrix protein 2; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; Splicing coactivator subunit SRm300; SR-related nuclear matrix protein of 300 kDa; SRL300; SRM300; SRRM2; Tax-responsive enhancer element-binding protein 803; TaxREB803; testicular secretory protein Li 53
Gene Symbols: SRRM2
Molecular weight: 299,615 Da
Basal Isoelectric point: 12.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein