OSBPL8 Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. Belongs to the OSBP family. Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 12q21.2
Cellular Component:  cytosol; endoplasmic reticulum membrane; integral component of membrane; nuclear membrane
Molecular Function:  cholesterol binding; phosphatidylinositol-4-phosphate binding; phosphatidylserine binding; phospholipid transporter activity
Biological Process:  activation of protein kinase B activity; fat cell differentiation; negative regulation of cell migration; negative regulation of sequestering of triglyceride; phosphatidylserine acyl-chain remodeling; phospholipid transport; positive regulation of glucose import; positive regulation of insulin receptor signaling pathway; positive regulation of protein kinase B signaling; protein localization to nuclear pore; sterol transport
Reference #:  Q9BZF1 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A11164; KIAA1451; MGC126578; MGC133203; MST120; MSTP120; ORP-8; ORP8; OSBL8; OSBP-related protein 8; OSBP10; OSBPL8; oxysterol binding protein-like 8; oxysterol-binding protein-like protein 8; Oxysterol-binding protein-related protein 8
Gene Symbols: OSBPL8
Molecular weight: 101,196 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below

OSBPL8

Protein Structure Not Found.


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