CDC5L DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Belongs to the CEF1 family. Ubiquitously expressed in both fetal and adult tissues. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; Prp19 complex; U2-type catalytic step 2 spliceosome
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; leucine zipper domain binding; protein binding; protein kinase binding; protein phosphatase 1 binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor binding; WD40-repeat domain binding
Biological Process:  cellular response to fibroblast growth factor stimulus; cellular response to interleukin-2; cellular response to nerve growth factor stimulus; cellular response to prolactin; cellular response to wortmannin; DNA repair; mitotic cell cycle; mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; signal transduction involved in DNA damage checkpoint
Reference #:  Q99459 (UniProtKB)
Alt. Names/Synonyms: CDC5; CDC5 (cell division cycle 5, S. pombe, homolog)-like; CDC5 cell division cycle 5-like; CDC5 cell division cycle 5-like (S. pombe); CDC5-LIKE; Cdc5-like protein; Cdc5-related protein; CDC5L; CEF1; cell division cycle 5 like; Cell division cycle 5, S. pombe, homolog-like; Cell division cycle 5-like protein; dJ319D22.1; dJ319D22.1 (CDC5-like protein); hCDC5; KIAA0432; PCDC5RP; Pombe cdc5-related protein
Gene Symbols: CDC5L
Molecular weight: 92,251 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene