CASC5 Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. May give rise to a MLL-CASC5 fusion protein. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Cell cycle regulation
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component:  acrosomal vesicle; condensed chromosome kinetochore; cytosol; nuclear body; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  acrosome assembly; attachment of spindle microtubules to kinetochore; cell division; CENP-A containing nucleosome assembly; negative regulation of phosphatase activity; protein localization to kinetochore
Disease: Microcephaly 4, Primary, Autosomal Recessive
Reference #:  Q8NG31 (UniProtKB)
Alt. Names/Synonyms: AF15q14; ALL1-fused gene from chromosome 15q14; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; Cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; kinetochore null 1 homolog; Kinetochore scaffold 1; Kinetochore-null protein 1; KNL1; Protein CASC5; Protein D40/AF15q14
Gene Symbols: KNL1
Molecular weight: 265,391 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB