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HN1
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation. Belongs to the JUPITER family. Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 17q25.1 |
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Cellular Component:
cytoplasm; nuclear membrane; nucleolus; nucleus
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Reference #:
Q9UK76
(UniProtKB)
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Alt. Names/Synonyms: Androgen-regulated protein 2; ARM2; hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1A; JPT1; JUPI1; Jupiter microtubule associated homolog 1; Jupiter microtubule associated homolog 1, N-terminally processed
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Gene Symbols: JPT1
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Molecular weight:
16,015 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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