HN1 Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation. Belongs to the JUPITER family. Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  cytoplasm; nuclear membrane; nucleolus; nucleoplasm; nucleus
Molecular Function:  protein binding
Reference #:  Q9UK76 (UniProtKB)
Alt. Names/Synonyms: Androgen-regulated protein 2; ARM2; hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1A; JPT1; JUPI1; Jupiter microtubule associated homolog 1; Jupiter microtubule associated homolog 1, N-terminally processed
Gene Symbols: JPT1
Molecular weight: 16,015 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein