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PCM-1
Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. Belongs to the PCM1 family. Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Oncoprotein |
| Chromosomal Location of human Ortholog: 8p22 |
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Cellular Component:
apical part of cell; centriolar satellite; centriole; centrosome; ciliary basal body; ciliary transition zone; cytoplasm; cytosol; non-motile cilium; nuclear membrane; nucleoplasm; pericentriolar material; protein-containing complex
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Molecular Function:
identical protein binding; molecular adaptor activity; protein binding
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Biological Process:
centrosome cycle; cilium assembly; cytoplasmic microtubule organization; interkinetic nuclear migration; intraciliary transport involved in cilium assembly; microtubule anchoring; microtubule anchoring at centrosome; negative regulation of neurogenesis; neuron migration; neuronal stem cell population maintenance; non-motile cilium assembly; positive regulation of intracellular protein transport; protein localization to centrosome; protein-containing complex localization to centriolar satellite; regulation of protein complex stability; social behavior
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Disease: Thyroid Carcinoma, Papillary
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Reference #:
Q15154
(UniProtKB)
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Alt. Names/Synonyms: hPCM-1; PCM-1; PCM1; pericentriolar material 1; Pericentriolar material 1 protein; pericentriolar material 1, PCM1; PTC4; RET/PCM-1
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Gene Symbols: PCM1
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Molecular weight:
228,560 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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