PSF a proline-and glutamine-rich splicing factor. Essential pre-mRNA splicing factor required early in spliceosome formation. Seems to also bind DNA. The active complex is a heterotetramer of two 52 kDa and two 100 kDa subunits. Reported to be a PKC-alpha-binding protein in the cell nucleus. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component:  chromatin; dendrite cytoplasm; nuclear matrix; nuclear speck; nucleoplasm; nucleus; paraspeckles; RNA polymerase II transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; histone deacetylase binding; protein binding; protein homodimerization activity; RNA polymerase II distal enhancer sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  activation of innate immune response; alternative mRNA splicing, via spliceosome; dendritic transport of messenger ribonucleoprotein complex; double-strand break repair via homologous recombination; histone H3 deacetylation; innate immune response; mRNA processing; negative regulation of circadian rhythm; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of sister chromatid cohesion; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; rhythmic process; RNA splicing
Reference #:  P23246 (UniProtKB)
Alt. Names/Synonyms: 100 kDa DNA-pairing protein; DNA-binding p52/p100 complex, 100 kDa subunit; hPOMp100; polypyrimidine tract-binding protein-associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; POMP100; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; SFPQ; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated); splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated); Splicing factor, proline- and glutamine-rich
Gene Symbols: SFPQ
Molecular weight: 76,149 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA