53BP1 Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Participates to the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 15q15.3
Cellular Component:  condensed chromosome kinetochore; cytoplasm; DNA repair complex; nuclear body; nuclear chromosome, telomeric region; nucleoplasm; nucleus; replication fork; site of double-strand break
Molecular Function:  damaged DNA binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II activating transcription factor binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding
Biological Process:  cellular response to DNA damage stimulus; cellular response to X-ray; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein homooligomerization
Reference #:  Q12888 (UniProtKB)
Alt. Names/Synonyms: 53BP1; FLJ41424; MGC138366; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; TP53B; TP53BP1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; Tumor suppressor p53-binding protein 1
Gene Symbols: TP53BP1
Molecular weight: 213,574 Da
Basal Isoelectric point: 4.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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53BP1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein