COPS1 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Belongs to the CSN1 family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of human Ortholog: 17q25.3
Cellular Component:  COP9 signalosome; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  GTPase inhibitor activity; protein binding
Biological Process:  JNK cascade; negative regulation of catalytic activity; protein deneddylation; protein neddylation; regulation of protein neddylation
Reference #:  Q13098 (UniProtKB)
Alt. Names/Synonyms: COP9 signalosome complex subunit 1; COPS1; CSN1; G protein pathway suppressor 1; GPS-1; GPS1; JAB1-containing signalosome subunit 1; MGC71287; Protein MFH; SGN1; Signalosome subunit 1
Gene Symbols: GPS1
Molecular weight: 55,537 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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