STX2 Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 12q13
Cellular Component:  basolateral plasma membrane; cell surface; cell-cell junction; cytoplasmic vesicle; endomembrane system; extracellular space; integral component of membrane; lamellipodium; membrane raft; midbody; plasma membrane; presynaptic active zone membrane; presynaptic membrane; SNARE complex; synapse; synaptic vesicle; transport vesicle
Molecular Function:  calcium-dependent protein binding; protein binding; protein dimerization activity; SNAP receptor activity; SNARE binding
Biological Process:  acrosome reaction; cell differentiation; cornified envelope assembly; digestive tract morphogenesis; epithelial cell differentiation; exocytosis; intracellular protein transport; intracellular transport; membrane fusion; microvillus assembly; protein complex oligomerization; response to hydroperoxide; synaptic vesicle fusion to presynaptic active zone membrane; vesicle docking; vesicle fusion; vesicle targeting; vesicle-mediated transport
Reference #:  P50279 (UniProtKB)
Alt. Names/Synonyms: Epim; Epimorphin; Stx2; syntaxin 2; Syntaxin-2
Gene Symbols: Stx2
Molecular weight: 33,359 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene