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hnRNP D0 iso3
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding |
| Chromosomal Location of human Ortholog: 4q21.22 |
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Cellular Component:
cytosol; glutamatergic synapse; mCRD-mediated mRNA stability complex; nucleoplasm; nucleus; postsynaptic density; ribonucleoprotein complex
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Molecular Function:
chromatin binding; histone deacetylase binding; minor groove of adenine-thymine-rich DNA binding; mRNA 3'-UTR AU-rich region binding; protein binding; RNA binding; telomeric DNA binding
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Biological Process:
3'-UTR-mediated mRNA destabilization; cellular response to amino acid stimulus; cellular response to estradiol stimulus; cellular response to nitric oxide; cellular response to putrescine; cerebellum development; circadian regulation of translation; CRD-mediated mRNA stabilization; hepatocyte dedifferentiation; liver development; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of cytoplasmic translation; positive regulation of DNA-templated transcription; positive regulation of telomerase RNA reverse transcriptase activity; positive regulation of telomere capping; positive regulation of translation; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gene expression; regulation of telomere maintenance; response to calcium ion; response to electrical stimulus; response to rapamycin; response to sodium phosphate; RNA catabolic process; RNA processing
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Reference #:
Q14103-3
(UniProtKB)
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Alt. Names/Synonyms: ARE-binding protein AUFI, type A; AU-rich element RNA binding protein 1, 37kDa; AU-rich element RNA-binding protein 1; AUF1; AUF1A; heterogeneous nuclear ribonucleoprotein D; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; hnRNP D0 iso3; HNRNPD; hnRNPD0; HNRPD; P37
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Gene Symbols: HNRNPD
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Molecular weight:
32,835 Da
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Basal Isoelectric point:
8.23
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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