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PDE6G
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Belongs to the rod/cone cGMP-PDE gamma subunit family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase |
| Chromosomal Location of human Ortholog: 17q25.3 |
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Cellular Component:
photoreceptor disc membrane; photoreceptor outer segment membrane; plasma membrane
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Molecular Function:
3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; enzyme inhibitor activity; protein binding; spectrin binding
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Biological Process:
positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; response to stimulus; visual perception
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Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 1; Retinitis Pigmentosa 57
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Reference #:
P18545
(UniProtKB)
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Alt. Names/Synonyms: CNRG; DKFZp686C0587; GMP-PDE gamma; MGC125749; PDE6G; PDEG; phosphodiesterase 6G; phosphodiesterase 6G, cGMP-specific, rod, gamma; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G; RP57
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Gene Symbols: PDE6G
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Molecular weight:
9,643 Da
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Basal Isoelectric point:
9.52
Predict pI for various phosphorylation states
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