PDE6G Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Belongs to the rod/cone cGMP-PDE gamma subunit family. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  photoreceptor disc membrane; plasma membrane
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; enzyme inhibitor activity; protein binding; spectrin binding
Biological Process:  activation of MAPK activity; negative regulation of catalytic activity; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; regulation of rhodopsin mediated signaling pathway; rhodopsin mediated signaling pathway; visual perception; Wnt signaling pathway, calcium modulating pathway
Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 57
Reference #:  P18545 (UniProtKB)
Alt. Names/Synonyms: CNRG; DKFZp686C0587; GMP-PDE gamma; MGC125749; PDE6G; PDEG; phosphodiesterase 6G, cGMP-specific, rod, gamma; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G
Gene Symbols: PDE6G
Molecular weight: 9,643 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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