PDE6G Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Belongs to the rod/cone cGMP-PDE gamma subunit family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 11 E2|11 84.14 cM
Cellular Component:  photoreceptor outer segment membrane
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; hydrolase activity; protein binding; spectrin binding
Biological Process:  activation of MAPK activity; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; response to stimulus; visual perception
Reference #:  P09174 (UniProtKB)
Alt. Names/Synonyms: cGMP phosphodiesterase gamma; CNRG; GMP-PDE gamma; OTTMUSP00000004609; p3AT; Pde; Pde6g; Pdeg; phosphodiesterase 6G, cGMP-specific, rod, gamma; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cyclic-GMP phosphodiesterase 6 gamma splice variant p3
Gene Symbols: Pde6g
Molecular weight: 9,637 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
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PDE6G

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene