KI-67 Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus
Chromosomal Location of Human Ortholog: 10q26.2
Cellular Component:  nuclear body; nucleolus; nucleus
Molecular Function:  ATP binding; DNA binding; protein binding; protein C-terminus binding
Biological Process:  cell cycle; cell proliferation; regulation of chromatin organization; regulation of chromosome segregation; regulation of mitotic nuclear division
Reference #:  P46013 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody Ki-67; Antigen KI-67; KI67; KIA; marker of proliferation Ki-67; MKI67; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen
Gene Symbols: MKI67
Molecular weight: 358,694 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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KI-67

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene