PER2 a transcription factor belonging to the basic helix-loop-helix (bHLH) family. A member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hr rhythm in the suprachiasmatic nucleus and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between per1 and per2 oscillations. The expression rhythms appear to originate from retina. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription factor
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component:  nucleolus; nucleus; perinuclear region of cytoplasm
Molecular Function:  protein binding; transcription coactivator activity; transcription regulatory region sequence-specific DNA binding
Biological Process:  circadian regulation of gene expression; circadian regulation of translation; circadian rhythm; fatty acid metabolic process; gluconeogenesis; glycogen biosynthetic process; histone H3 deacetylation; lactate biosynthetic process; negative regulation of circadian rhythm; negative regulation of fat cell proliferation; negative regulation of protein ubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of transcription regulatory region DNA binding; negative regulation of transcription, DNA-templated; positive regulation of cold-induced thermogenesis; positive regulation of nucleic acid-templated transcription; regulation of cell cycle; regulation of circadian rhythm; regulation of glutamate uptake involved in transmission of nerve impulse; regulation of insulin secretion; regulation of neurogenesis; regulation of vasoconstriction; response to ischemia; white fat cell differentiation
Disease: Advanced Sleep Phase Syndrome, Familial, 1
Reference #:  O15055 (UniProtKB)
Alt. Names/Synonyms: Circadian clock protein PERIOD 2; FASPS; hPER2; KIAA0347; PER2; period 2; period circadian protein 2; Period circadian protein homolog 2; period homolog 2 (Drosophila)
Gene Symbols: PER2
Molecular weight: 136,579 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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