GABRB2 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 11 A5|11 25.08 cM
Cellular Component:  cell junction; chloride channel complex; cytoplasmic vesicle; cytosol; GABA receptor complex; GABA-A receptor complex; GABA-ergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic specialization membrane; membrane; neuron projection; plasma membrane; postsynaptic membrane; synapse
Molecular Function:  chloride channel activity; GABA-A receptor activity; inhibitory extracellular ligand-gated ion channel activity; ion channel activity; protein binding; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; chloride transport; cochlea development; gamma-aminobutyric acid signaling pathway; inhibitory synapse assembly; inner ear receptor cell development; innervation; ion transmembrane transport; ion transport; negative regulation of neuron apoptotic process; negative regulation of neuron death; nervous system process; neuron development; regulation of membrane potential; regulation of neuron apoptotic process; sensory perception of sound; signal transduction; synaptic transmission, GABAergic
Reference #:  P63137 (UniProtKB)
Alt. Names/Synonyms: AI834970; C030002O17Rik; C030021G16Rik; GABA(A) receptor subunit beta-2; Gabrab2; Gabrb-2; Gabrb2; gamma-aminobutyric acid (GABA) A receptor, subunit beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; OTTMUSP00000006670
Gene Symbols: Gabrb2
Molecular weight: 59,197 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene