Cezanne Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin. Belongs to the peptidase C64 family. Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cysteine-type peptidase activity; DNA binding; hydrolase activity; K63-linked polyubiquitin modification-dependent protein binding; Lys48-specific deubiquitinase activity; metal ion binding; peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding
Biological Process:  adaptive immune response; immune system process; mucosal immune response; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interleukin-8 production; negative regulation of protein localization to nucleus; negative regulation of transcription by RNA polymerase II; protein deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis
Reference #:  B2RUR8 (UniProtKB)
Alt. Names/Synonyms: 2900060B22Rik; 4930463P07Rik; AI462125; CEZANNE; OTTMUSP00000024551; OTTMUSP00000024552; OTU domain containing 7B; OTU domain-containing protein 7B; Otud7b; Otud7b protein; Trabid2; TRAF binding domain containing 2; Za20d1; zinc finger, A20 domain containing 1
Gene Symbols: Otud7b
Molecular weight: 91,983 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene