CDK11B a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CDK family; CDK/PITSLRE subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Motility/polarity/chemotaxis; PITSLRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4 E2|4 86.73 cM
Cellular Component:  nucleus
Molecular Function:  ATP binding; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  blastocyst development; cell cycle; negative regulation of apoptotic signaling pathway; phosphorylation; protein amino acid phosphorylation; regulation of gene expression; regulation of mitotic cell cycle; regulation of mitotic nuclear division; regulation of mRNA processing
Reference #:  P24788 (UniProtKB)
Alt. Names/Synonyms: AA989746; Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110; CDK11-p46; CDK11-p58; Cdk11b; cell division cycle 2 homolog-like 1; cell division cycle 2 homolog-like 2; cell division cycle 2-like 1; cell division cycle 2-like 2; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11; Cyclin-dependent kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; OTTMUSP00000011463; OTTMUSP00000011464; p58; PITSLRE; PITSLRE proteins; PITSLRE serine/threonine-protein kinase CDC2L1
Gene Symbols: Cdk11b
Molecular weight: 91,513 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein