CTPS This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. Belongs to the CTP synthase family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine
Chromosomal Location of mouse Ortholog: 4 D2.2|4 56.52 cM
Cellular Component:  cytoophidium; cytoplasm
Molecular Function:  ATP binding; CTP synthase activity; identical protein binding; ligase activity; nucleotide binding
Biological Process:  B cell proliferation; CTP biosynthetic process; glutamine metabolic process; immune system process; pyrimidine nucleobase biosynthetic process; pyrimidine nucleotide biosynthetic process; T cell proliferation
Reference #:  P70698 (UniProtKB)
Alt. Names/Synonyms: CTP synthase 1; CTP synthetase 1; Ctps; Ctps1; cytidine 5'-triphosphate synthase; OTTMUSP00000009199; PYRG1; UTP--ammonia ligase 1
Gene Symbols: Ctps
Molecular weight: 66,682 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene