EIF4G2 a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 7 E3|7 58.0 cM
Cellular Component:  axon; cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; postsynaptic density
Molecular Function:  mRNA binding; protein binding; RNA binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  cellular macromolecule biosynthetic process; negative regulation of autophagy; positive regulation of axon extension; positive regulation of cell growth; positive regulation of dendritic spine development; positive regulation of translation; regulation of translation; regulation of translational initiation; translation; translational initiation
Reference #:  Q62448 (UniProtKB)
Alt. Names/Synonyms: AA589388; apobec-1 target 1; DAP-5; E130105L11Rik; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; Eif4g2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4, gamma 2; IF4G2; Nat1; Natm1; Novel APOBEC-1 target 1; p97; Translation repressor NAT1
Gene Symbols: Eif4g2
Molecular weight: 102,106 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EIF4G2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene