GEMIN3 The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Belongs to the DEAD box helicase family. DDX20 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA splicing
Chromosomal Location of mouse Ortholog: 3|3 F2.2
Cellular Component:  cytoplasm; cytosol; nucleus; RNA polymerase II transcription repressor complex; SMN complex; SMN-Sm protein complex; transcription repressor complex
Molecular Function:  ATP binding; DNA binding; DNA-binding transcription factor binding; helicase activity; histone deacetylase binding; hydrolase activity; nucleic acid binding; nucleotide binding; protein binding; protein domain specific binding; protein-macromolecule adaptor activity; ribonucleoside triphosphate phosphatase activity; RNA binding; RNA helicase activity
Biological Process:  mRNA processing; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; oogenesis; positive regulation of apoptotic process; regulation of steroid biosynthetic process; RNA splicing; spliceosomal snRNP assembly
Reference #:  Q9JJY4 (UniProtKB)
Alt. Names/Synonyms: Component of gems 3; Ddx20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box helicase 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; dp10; Dp103; GEMI; Gemin-3; Gemin3; MGC159174; Probable ATP-dependent RNA helicase DDX20; Regulator of steroidogenic factor 1; ROSF-1
Gene Symbols: Ddx20
Molecular weight: 91,710 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below

GEMIN3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA