RNF180 E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5q12.3
Cellular Component:  integral component of membrane; nuclear envelope
Molecular Function:  metal ion binding
Biological Process:  adult behavior; positive regulation of protein ubiquitination; protein polyubiquitination; regulation of catalytic activity
Reference #:  Q86T96 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF180; MGC120326; MGC120328; RINES; RING finger protein 180; RING-type E3 ubiquitin transferase RNF180; RN180; RNF180
Gene Symbols: RNF180
Molecular weight: 68,254 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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