DEAF1 a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  cytoplasm; extracellular region; fibrillar center; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  behavioral fear response; embryonic skeletal system development; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neural tube closure; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of mammary gland epithelial cell proliferation; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; visual learning
Reference #:  O88450 (UniProtKB)
Alt. Names/Synonyms: DEAF-1 related transcriptional regulator (NUDR); Deaf1; deformed epidermal autoregulatory factor 1 (Drosophila); Deformed epidermal autoregulatory factor 1 homolog; Nuclear DEAF-1-related transcriptional regulator; NUDR; Spn; Suppressin
Gene Symbols: Deaf1
Molecular weight: 59,532 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene