DYNC1I2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Belongs to the dynein intermediate chain family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of mouse Ortholog: 2 C2|2 42.38 cM
Cellular Component:  cytoplasm; cytoplasmic dynein complex; cytoskeleton; microtubule
Molecular Function:  dynein heavy chain binding; dynein light chain binding; motor activity; protein binding; protein-containing complex binding
Biological Process:  microtubule-based movement; negative regulation of neuron projection development
Reference #:  O88487 (UniProtKB)
Alt. Names/Synonyms: 3110079H08Rik; AW554389; Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; Dnci; Dnci2; Dncic2; Dync1i2; dynein cytoplasmic 1 intermediate chain 2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2; OTTMUSP00000014162; OTTMUSP00000018980
Gene Symbols: Dync1i2
Molecular weight: 68,394 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene