DYNC1I2
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Belongs to the dynein intermediate chain family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
Chromosomal Location of mouse Ortholog: 2 C2|2 42.38 cM |
Cellular Component:
centrosome; cytoplasm; cytoplasmic dynein complex; cytoskeleton; dynein complex; microtubule; outer dynein arm; vesicle
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Molecular Function:
dynein heavy chain binding; dynein light chain binding; protein binding; protein-containing complex binding
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Biological Process:
microtubule-based movement; negative regulation of neuron projection development; transport along microtubule
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Reference #:
O88487
(UniProtKB)
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Alt. Names/Synonyms: 3110079H08Rik; AW554389; Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; Dnci; Dnci2; Dncic2; Dync1i2; dynein cytoplasmic 1 intermediate chain 2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2; OTTMUSP00000014162; OTTMUSP00000018980
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Gene Symbols: Dync1i2
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Molecular weight:
68,394 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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