DYNC1I2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Belongs to the dynein intermediate chain family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 3q22
Cellular Component:  centrosome; cytoplasm; cytoplasmic dynein complex; microtubule; vesicle
Molecular Function:  dynein heavy chain binding; dynein light chain binding; protein-containing complex binding
Biological Process:  brain development; cellular response to nerve growth factor stimulus; microtubule-based movement; negative regulation of neuron projection development
Reference #:  Q62871 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; Dnci2; Dncic2; Dync1i2; dynein cytoplasmic 1 intermediate chain 2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; MGC93277
Gene Symbols: Dync1i2
Molecular weight: 71,178 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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DYNC1I2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene