NKAP Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the NKAP family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: X|X A3.3
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin binding; chromatin DNA binding
Biological Process:  granulocyte differentiation; hematopoietic stem cell proliferation; hemopoiesis; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Notch signaling pathway; positive regulation of alpha-beta T cell differentiation; stem cell population maintenance; T cell differentiation in thymus
Reference #:  Q9D0F4 (UniProtKB)
Alt. Names/Synonyms: 2610020O08Rik; AA987160; AI849147; AL024236; NF-kappa-B-activating protein; NFKB activating protein; Nkap; nuclear NF-kappaB activating protein; OTTMUSP00000018614
Gene Symbols: Nkap
Molecular weight: 47,227 Da
Basal Isoelectric point: 10.12  Predict pI for various phosphorylation states
Select Structure to View Below

NKAP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene